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NAD+

Is a very special molecule that has everything to do with why we age and the corresponding declines we experience in quality of life. NAD is essential to the creation of energy in the body and the regulation of pivotal cellular processes. Scientists think NAD+ may be the key to unlocking lifespans of greater than 120 years. While most anti-aging products try to reverse signs of aging on your skin, NAD+ aims to reverse signs of aging from inside your body.

Strength & Endurance

Enhance Energy Metabolism

Anti Aging

Neuro Protection

DNA Repair

NAD+ is a crucial cofactor of epigenetic function. Epigenetics is our genome’s capacity to turn on or off the right genes at the right time.

NAD+ supports Mitochondrial function increasing stamina. Mitochondria are the powerhouse of the cell, the underlying energy generation system of the body.

NAD+ tunes your immune system. It can also modulate down the immune system which mitigates various autoimmune disorders.

Decreasing NAD+ level is also associated with age-related DNA damage. In our modern day face paced lives our DNA struggles to replicate itself perfectly, which can cause sickness and disease. NAD+ protects our DNA from toxins and free radicals that threaten our health.

While most anti-aging products try to reverse signs of aging on your skin, NAD+ Nicotinamide Adenine Dinucleotide aims to reverse signs of aging from inside your body. However, the amount of NAD+ in your body naturally falls with age – PubMed .

Low NAD+ levels have been linked to health concerns like aging and chronic illnesses, such as diabetes, heart disease, Alzheimer’s disease and vision loss – Pubmed.

Interestingly, animal research has found that raising NAD+ levels may help reverse signs of aging and lower the risk of many chronic diseases Pubmed | PubMed | PubMed

 

NAD+ is a coenzyme, or helper molecule, that acts as fuel for many key biological processes, such as:

  • Converting food into energy
  • Repairing damaged DNA
  • Fortifying cells’ defense systems
  • Setting your body’s internal clock or circadian rhythm

 Pubmed | PubMed

Activates Enzymes That May Promote Healthy Aging

NAD+ activates certain enzymes that may promote healthy aging.

One group is sirtuins, which appear to improve lifespan and overall health in animals. Studies indicate that sirtuins may repair damaged DNA, boost stress resistance, reduce inflammation and offer other benefits that promote healthy aging Pubmed | Pubmed.

Sirtuins are also responsible for the lifespan-extending benefits of calorie restriction PubMed.

Another group is Poly (ADP-Ribose) polymerases (PARPs), which repair damaged DNA. Studies link higher PARP activity to less DNA damage and a longer lifespan Pubmed | Pubmed.

 

May Help Protect Brain Cells

NAD+ plays a key role in helping your brain cells age well.

Within brain cells, NAD+ helps control the production of PGC-1-alpha, a protein that appears to help protect cells against oxidative stress and impaired mitochondrial function Pubmed.

Researchers believe both oxidative stress and impaired mitochondrial function are linked to age-related brain disorders such as Alzheimer’s and Parkinson’s disease Pubmed | Pubmed | Pubmed.

In mice with Alzheimer’s disease, nicotinamide riboside raised brain NAD+ levels and PGC-1-alpha production by up to 70% and 50%, respectively. By the end of the study, the mice performed significantly better in memory-based tasks (4Trusted Source).

In a test-tube study, nicotinamide riboside raised NAD+ levels and significantly improved mitochondrial function in stem cells taken from a Parkinson’s disease patient Pubmed.

However, it’s still not clear how helpful it is to raise NAD+ levels in people with age-related brain disorders. More human studies are needed.

 

May Lower Heart Disease Risk

Aging is a major risk factor for heart disease, which is the world’s leading cause of death Pubmed.

It can cause blood vessels like your aorta to become thicker, stiffer and less flexible. Such changes can raise blood pressure levels and make your heart work harder.

In animals, raising NAD+ helped reverse age-related changes to arteries Pubmed.  In humans, nicotinamide riboside raised NAD+ levels, helped reduce stiffness in the aorta and lowered systolic blood pressure in adults at risk of high blood pressure Science Direct.

 

Other Potential Benefits

In addition, nicotinamide riboside may provide several other benefits:

  • May aid weight loss: NAD+ helped speed up the metabolism of mice. However, it’s unclear whether it would have the same effect in humans and how strong this effect really is Pubmed.
  • May lower cancer risk: High NAD+ levels help protect against DNA damage and oxidative stress, which are linked to cancer development (Pubmed | Pubmed.
  • May help treat jet lag: NAD+ helps regulate your body’s internal clock, so taking niagen may help treat jet lag or other circadian rhythm disorders by resetting your body’s internal clock Pubmed.
  • May promote healthy muscle aging: Raising NAD+ levels helped improve muscle function, strength and endurance in older mice (Pubmed | Pubmed.