Is a very special molecule that has everything to do with why we age and the corresponding declines we experience in quality of life. NAD is essential to the creation of energy in the body and the regulation of pivotal cellular processes. Scientists think NAD+ may be the key to unlocking lifespans of greater than 120 years. While most anti-aging products try to reverse signs of aging on your skin, NAD+ aims to reverse signs of aging from inside your body.
Strength & Endurance
Enhance Energy Metabolism
NAD+ is a crucial cofactor of epigenetic function. Epigenetics is our genome’s capacity to turn on or off the right genes at the right time.
NAD+ supports Mitochondrial function increasing stamina. Mitochondria are the powerhouse of the cell, the underlying energy generation system of the body.
NAD+ tunes your immune system. It can also modulate down the immune system which mitigates various autoimmune disorders.
Decreasing NAD+ level is also associated with age-related DNA damage. In our modern day face paced lives our DNA struggles to replicate itself perfectly, which can cause sickness and disease. NAD+ protects our DNA from toxins and free radicals that threaten our health.
While most anti-aging products try to reverse signs of aging on your skin, NAD+ Nicotinamide Adenine Dinucleotide aims to reverse signs of aging from inside your body. However, the amount of NAD+ in your body naturally falls with age
Low NAD+ levels have been linked to health concerns like aging and chronic illnesses, such as diabetes, heart disease, Alzheimer’s disease and vision loss
Activates Enzymes That May Promote Healthy Aging
NAD+ activates certain enzymes that may promote healthy aging.
One group is sirtuins, which appear to improve lifespan and overall health in animals. Studies indicate that sirtuins may repair damaged DNA, boost stress resistance, reduce inflammation and offer other benefits that promote healthy aging
Sirtuins are also responsible for the lifespan-extending benefits of calorie restriction
May Help Protect Brain Cells
NAD+ plays a key role in helping your brain cells age well.
Within brain cells, NAD+ helps control the production of PGC-1-alpha, a protein that appears to help protect cells against oxidative stress and impaired mitochondrial function
In mice with Alzheimer’s disease, nicotinamide riboside raised brain NAD+ levels and PGC-1-alpha production by up to 70% and 50%, respectively. By the end of the study, the mice performed significantly better in memory-based tasks (
In a test-tube study, nicotinamide riboside raised NAD+ levels and significantly improved mitochondrial function in stem cells taken from a Parkinson’s disease patient
However, it’s still not clear how helpful it is to raise NAD+ levels in people with age-related brain disorders. More human studies are needed.
May Lower Heart Disease Risk
Aging is a major risk factor for heart disease, which is the world’s leading cause of death
It can cause blood vessels like your aorta to become thicker, stiffer and less flexible. Such changes can raise blood pressure levels and make your heart work harder.
In animals, raising NAD+ helped reverse age-related changes to arteries
Other Potential Benefits
In addition, nicotinamide riboside may provide several other benefits:
- May aid weight loss: NAD+ helped speed up the metabolism of mice. However, it’s unclear whether it would have the same effect in humans and how strong this effect really is
- May lower cancer risk: High NAD+ levels help protect against DNA damage and oxidative stress, which are linked to cancer development (
- May help treat jet lag: NAD+ helps regulate your body’s internal clock, so taking niagen may help treat jet lag or other circadian rhythm disorders by resetting your body’s internal clock
- May promote healthy muscle aging: Raising NAD+ levels helped improve muscle function, strength and endurance in older mice (
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